"We should be cautious but cognizant of potentially historic opportunities," Rose Gottemoeller, US assistant secretary of state for arms control told a UN disarmament committee.
"We must continue to push to bring Iran back into line with its international nuclear obligations," Gottemoeller told the forum, which included Iranian diplomats.
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"The road toward the next steps might not be familiar and it will require difficult negotiations and complicated diplomacy," said the US official.
Western nations say they are waiting for the Iranian government to follow up on statements made by President Hassan Rouhani that his country wants an accord to end western doubts about Iran's nuclear drive.
The United States, Britain and France say they believe Iran seeks a nuclear bomb capability. Iran, which is under several rounds of UN sanctions over its uranium enrichment, denies the charge.
European foreign policy chief Catherine Ashton -- negotiating for the United States, Russia, Britain, France, Germany and China -- is to meet with Iranian negotiators in Geneva next Tuesday.
Western diplomats say this will be a first chance to test Iran's intentions. Rouhani said he wanted a deal within a year. US President Barack Obama has insisted though that Iran must follow up with concrete actions.
Gottemoeller said North Korea, which like Iran faces UN sanctions over its nuclear program, must also "meet its own denuclearization commitments."
"It too can have an opportunity to reintegrate into the international community if it does so," the US official added.
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