Shares were also hit as blue-chips, including Reliance Industries fell on profit-taking ahead of European Central Bank's policy decision later in the day and monthly US jobs data on Friday.
Nifty fell 0.24 per cent after earlier rising as much as 0.36 per cent to a lifetime high of 6,776.75.
The falls marked the index's first fall in 11 sessions.
Still, heavy foreign buying has continued to underpin share gains. Foreign investors bought a net Rs 595 crore worth of shares on Wednesday, bringing the total since February to nearly $3.5 billion.
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