Enzyme's role in muscle ageing discovered

British researchers have identified the role of an enzyme in muscle wasting and associated age-related problems.

According to the team from the University of Birmingham, inhibiting the enzyme can hold the key to developing ways of preventing, or reversing, the adverse effects of muscle atrophy.

The research is a significant step in understanding the role played by this key enzyme involved in the degenerative effects of ageing.

During the research, the expression of this enzyme, responsible for activating the steroid hormone cortisol, was increased in the muscles of older females.

The findings in 134 healthy volunteers showed that expression of the enzyme in skeletal muscles increased 2.72-fold in women aged over 60 years of age.

In male participants, no difference was seen.

"As yet, we do not know why it appears to only occur in women. We are planning to look at whether hormones such as oestrogens could be involved," said Zaki Hassan-Smith from the University of Birmingham.

At present, there is no pharmacological treatment for muscle atrophy but pharmaceutical companies are developing and testing inhibitors of this key enzyme with a focus on treatments for such conditions as diabetes.

The paper was published in the Journal of Clinical Endocrinology & Metabolism,