The explosion today happened near a building with administrative offices for Egypt's Ministry of Foreign Affairs and caused minor damage to the structure. Associated Press video showed the busy street littered with broken glass and rubble immediately after the blast.
MENA quoted the Ministry of Health as saying the two victims were taken to a hospital but did not give their conditions.
There was no immediate claim of responsibility.
Egypt faces a burgeoning insurgency, including a branch of the Islamic State group. Attacks have primarily targeted security forces in the restive northern Sinai, but are now happening regularly in the capital.
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