The attackers targeted a security forces' convey when it was passing through Sariab road in the provincial capital Quetta, police officials said.
The officials confirmed that it was a suicide bomb attack on security forces convoy.
"The target was the vehicle of the FC commander, but he was not present in the vehicle when the bomb attack took place," a government official said.
A spokesperson for Civil hospital Quetta said that they had received four dead bodies while 19 persons, including a child, were injured in the bomb explosion.
The attack came a day after senior police official of Khyber-Pakhtunkhwa Ashraf Noor was killed in a suicide attack on his vehicle in the upscale Hayatabad neighbourhood of Peshawar.
No group has claimed responsibility for the attack but Taliban militants and Baloch nationalists often target security forces in the area.
A senior Pakistani police officer and his three family members were killed by unidentified, motorcycle-borne militants in Balochistan on November 15.
Senior Superintendent of Police (SSP) Muhammad Illyas who was on his way to market when he was killed in a targeted attack along with his wife, son and five-year-old granddaughter.
Balochistan has been rocked by a series of attacks which raised concerns about a growing militant presence, including those affiliated with Islamic State, which has claimed several bombings in the restive province.
The unrest has raised security concerns for projects in the USD 50 billion China Pakistan Economic Corridor, a transport and energy link from western China to Pakistan's southern Gwadar port.
At least six police commandos and a civilian were killed last month when an explosives-laden vehicle rammed into a security force's convoy on the Quetta-Sibi Highway.
In June this year, 14 people, including seven policemen, were killed and 21 others were injured in a suicide car bombing on Gulistan Road in Balochistan.
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