A statement by the 12 leaders after an Asia-Pacific Economic Cooperation summit in Bali said they made "significant progress" in setting standards for trade in goods and services, and for investment and public procurement.
It said they agreed "to resolve all outstanding issues with the objective of completing this year a comprehensive and balanced, regional agreement."
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One aim is to significantly boost US exports to the region and create jobs. The nations involved are Australia, Brunei Darussalam, Canada, Chile, Japan, Malaysia, Mexico, New Zealand, Peru, Singapore, United States, and Vietnam.
US Trade Representative Michael Froman said a deal is in reach but its quality shouldn't be sacrificed to meet a deadline.
"I think there is so much focus right now and momentum behind this," he said. "That is a very positive dynamic for trying to resolve the remaining issues."
Intellectual property protection and policies that give state-owned companies an unfair commercial advantage are among the issues still being haggled over.
Some civil groups have been concerned that patent and investment provisions in the agreement could allow international companies to usurp national sovereignty and laws in areas such as health care.
The commitment to reaching an agreement by the end of the year came despite President Barack Obama missing the summit to deal with the US budget impasse.
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