Fifteen of the dead, among them four of the children, came in the barrel bomb strike on a rebel-held district of the divided northern city, the Syrian Observatory for Human Rights said.
"The children were aged under 10," said Observatory chief Rami Abdel Rahman, adding that a pregnant woman was also among the dead.
The crude explosives-filled container hit a building in the northeastern neighbourhood of Karam al-Beik as residents were sitting down to the iftar meal, which breaks the daytime fast observed during the Muslim holy month of Ramadan.
For the past three years, Syria's pre-war economic hub has been divided between a government-held western sector and a rebel-held eastern one.
The rebels launched a major offensive in the first week of July to try to advance the front line.
More than 220,000 people have been killed in Syria since the conflict began with anti-government protests in March 2011 that were met with a bloody crackdown.
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