The Yamalo-Nenetsky region, some 2,000 kilometres northeast of Moscow, has been under quarantine for a week after the deadly bacterium infected at least nine nomadic reindeer herders and their animals.
"I've been told of the death of a boy in our hospital. I have no words to express my feelings," governor Dmitry Kobylkin said.
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"The infection showed its cunning. Returning after 75 years, it took away a child's life," said Kobylkin.
A total of 72 people, 41 of them children, have been hospitalised on suspicion of infection in the main city of Salekhard.
So far nine have tested positive for anthrax, including the boy who died, the regional authorities said Monday.
More than 2,300 reindeer have been killed in the outbreak in the region where more than 250,000 of the animals roam, the authorities said.
The authorities said they were carrying out vaccinations of people and reindeer and giving those who visited the quarantine area antibacterial medicines.
The infection was identified on June 25 after numerous deaths among reindeer, the sanitary medicine service for the region said on Monday.
Russia's chief sanitary doctor Anna Popova visited the region last week, saying the site of the infection had been "isolated" and the region had enough vaccines and antibiotics.
Popova said that there had been no cases of anthrax in the region among people or animals since 1941 and it had been considered formally free of the infection since 1968.
The regional authorities linked the outbreak to unusually hot weather, with more than a month of temperatures up to 35 degrees celsius that melted the permafrost and activated the deadly spores.
"The anthrax spores lay in wait in the permafrost for more than a century," said the agriculture watchdog agency.
Anthrax does not spread directly from one infected human or animal to another, but is spread through spores. Humans can contract anthrax from handling diseased animals or eating infected meat.
The potentially lethal bacterium exists naturally in the soil and commonly infects livestock which ingest or inhale its spores while grazing.
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