Britain's EU departure on Friday marks a "sea change" for the bloc, Chancellor Angela Merkel's spokesman said.
"It is clearly a sea change for Europe because the UK was an important member of the EU for 47 years -- nearly half a century," said Steffen Seibert said at a government press conference.
Berlin hopes Britain will continue to be a "close partner and friend", Seibert added.
"We regret (Brexit), and we think the majority of the German population feel the same, but we respect the decision made by the British people."
"European integration has brought Europe peace and prosperity... We and the other 26 remaining member states are determined to continue this success story."
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