EU Parliament President Martin Schulz said he would speak with German Chancellor Angela Merkel "on how we can avoid a chain reaction" of other EU states following.
"The chain reaction that is being celebrated everywhere now by euroskeptics won't happen," he said.
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"That will have consequences and I don't believe other countries will be encouraged to follow that dangerous path."
"I am not shocked," he said of the results of the British referendum, adding: "We were prepared."
Schulz added that he expected British Prime Minister David Cameron to speak at a special session of the European Parliament on Tuesday, and that negotiations would start soon over Britain's exit.
German Finance Minister Wolfgang Schaeuble noted that the procedures for a withdrawal from the EU are clearly defined and will be applied. This provides reliability.
"Europe must now stand together. Together we will make the best out of the decision of our British friends," he added.
German Foreign Minister Frank-Walter Steinmeier also regretted Britain's decision to leave the EU, calling it a "sad day for Europe".
"The early morning news from #GreatBritain are truly sobering. It looks like a sad day for #Europe +the #UnitedKingdom," Steinmeier wrote on Twitter.
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