In an address to an annual gathering of central bankers in Wyoming, Yellen took note of strong job growth, saying gradual increases in the Fed's benchmark rate in the coming years should be expected.
"In light of the continued solid performance of the labor market and our outlook for economic activity and inflation, I believe the case for an increase in the federal funds rate has strengthened in recent months," Yellen said, according to her prepared remarks.
Sure to ripple through equities and commodities markets, Yellen's words returned a measure of clarity on the intentions of US monetary policymakers, who have been publicly at odds in recent months over the need to raise rates in the near-term.
Her remarks raised the likelihood that the Fed will increase the rate from its current ultra-low 0.25-0.50 percent level by the end of the year, and as early as its next meeting in September.
The Fed had at the end of 2015 raised rates for the first time in nearly decade, ending the policies designed to respond immediately to the Great Recession.
But policy makers quickly veered off this course early this year, fearing that the US economy was growing more weekly than they had foreseen and global risks, especially from China and Europe, had risen.
"Our ability to predict how the federal funds will evolve over time is quite limited because monetary policy will need to respond to whatever disturbances may buffet the economy," Yellen says, adding that some such conditions were visible "only in hindsight."
"For these reasons, the range of reasonably likely outcomes for the federal funds rate is quite wide."
Yellen cited research according to which there was a 70 percent probability that rates would be between 0 percent and 3.25 percent by the end of 2017. The range expanded to 0-4.5 percent by the end of 2018.
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