Cell division finding could boost understanding of cancer

Fresh insights into how cells in human bodies divide could improve knowledge of a condition linked to cancer, a new study suggests.
Errors in the cell division process, which allows humans to grow and stay healthy, can lead to a genetic disorder called aneuploidy, which is also associated with birth defects and infertility.
Researchers at the University of Edinburgh have pinpointed the key role played by a protein in ensuring that cells separate correctly.
During cell division, chromosomes containing DNA duplicate and then separate to form two identical copies of the original cell.
Aneuploidy arises when chromosome pairs fail to separate properly.

Scientists say a protein called shugoshin serves two important functions - it recruits other parts of the cell needed for chromosome separation, and enables an in-built error correction system to monitor cells as they divide.

Researchers studied the effect that disabling shugoshin had on cell division in yeast.
The team found that in the absence of working shugoshin protein, cells were more likely to contain abnormal numbers of chromosomes.
Cell division in yeast is very similar to that of humans, making it an excellent model to study the role that shugoshin plays in preventing aneuploidy in people.
The study, published in the journal eLife, was funded by Wellcome Trust, European Molecular Biology Organisation, Scottish Universities Life Sciences Alliance and Darwin Trust of Edinburgh.

Adele Marston of the University of Edinburgh's School of Biological Sciences, who led the study, said: "Faults in these proteins are linked to some types of cancer, and our new discoveries about how they function in yeast could help us understand how they can sometimes contribute to disease in humans.