The two-day meeting in Lusaka is the African Union's first conference on "Ending Child Marriage in Africa", gathering representatives from member states as well as first ladies, UN officials and civil society groups.
"The total number of child brides will rise from 125 million to 310 million by 2050... If we do not do something now," UNICEF deputy executive director Fatoumata Ndiaye told AFP.
"That means that the face of child marriage will be Africa," eclipsing South Asia, which currently has the highest number of child brides, Ndiaye said in a phone interview from Lusaka.
"The child population of Africa is expected to grow rapidly in the coming years putting millions more girls at risk" of early marriage, said UNICEF in a report published as the meeting opened in Zambia.
Africa's population of girls is expected to balloon from the current 275 million to 465 million within 35 years.
"By 2050 we will have ... More teenagers marrying in Africa than anywhere else in the world.
"So it makes it extremely important to do something today and not to wait any more," said Ndiaye.
The African Union estimates that about 14 million under-age girls are married on the continent each year -- almost all of them forced to by their parents, often against laws that are rarely enforced.
"Child marriage is a human rights violation that robs girls of their rights to health, to live in security, and to choose if, when and whom to marry," the AU said ahead of the meeting.
"It is a harmful practice which severely affects the rights of a child."
Girls married early face a greater risk of domestic violence, contracting HIV and are likely to die or face complications while giving birth, according to the global coalition Girls Not Brides.
Some of the highest rates of under-age marriage in Africa are in Mauritania, Niger, Chad and the Central African Republic while Nigeria, with 23 million, is home to the largest number of child brides.
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