Analysts noted however that no damage to copper facilities had been reported.
At about 0100 GMT, copper climbed to USD 6,728.75 per tonne, striking the highest point since March 10.
In later deals on the London Metal Exchange, the industrial metal pulled back to stand at USD 6,697.75.
"Copper has hit a three-week high as an enormous earthquake off the coast of Chile as sparked fears of a tsunami," said analyst David Madden at trading firm IG.
Chile is the biggest copper producer in the world and accounts for almost one-third of global supplies.
"The copper price climbed temporarily to a three-week high of over USD 6,700 per tonne after a severe earthquake occurred off the coast of Chile overnight, giving rise to concerns about supply outages," noted Commerzbank analyst Carsten Fritsch.
"So far, however, there have been no reports of any damage, and some mining companies have already sounded the all-clear."
Copper has experienced volatile trading so far this year, diving last month on demand worries in top global consumer China.
The base metal had dived on March 19 to USD 6,321 per tonne, which was the lowest point since July 2010.
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