On February 14, a former student, Nicolas Cruz, 19, opened fire at Marjory Stoneman Douglas High School in Parkland, Florida, killing at least 17.
The march, to be held on Match 24, was announced by five teenagers who survived the deadly shooting.
"Amal and I are so inspired by the courage and eloquence of these young men and women from Stoneman Douglas High School.
Taking a leaf out of the Clooneys' book, Winfrey also announced her addition of USD 500,000 donation to the cause.
"George and Amal, I couldn't agree with you more. I am joining forces with you and will match your USD 500,000 donation to 'March For Our Lives', These inspiring young people remind me of the Freedom Riders of the 60s who also said we've had ENOUGH and our voices will be heard," Winfrey wrote on Twitter.
"The young students in Florida and now across the country are already demonstrating their leadership with a confidence and maturity that belies their ages.
"Kate and I applaud their efforts to take a stand for the benefit of this and future generations. They are an inspiration to us all, and we are joining in this movement with a donation of USD 500,000," Spielberg said in a statement.
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