"The Department of Homeland Security (DHS) is closely monitoring the situation at Manchester Arena in the United Kingdom," an official statement here said.
"We are working with our foreign counterparts to obtain additional information about the cause of the reported explosion as well as the extent of injuries and fatalities," the DHS said.
A powerful blast ripped through the crowded arena hosting US star Ariana Grande's pop concert in Manchester, killing 19 people and injuring over 50 others, in one of the deadliest terror attacks in the UK.
The DHS also urged US citizens in the area to pay heed to the directions from the local authorities and maintain security awareness.
"At this time, we have no information to indicate a specific credible threat involving music venues in the United States," the DHS said.
"However, the public may experience increased security in and around public places and events as officials take additional precautions," it said.
Reacting to the news of the blast in Manchester, House Speaker Paul Ryan said, "Young and innocent lives lost in Manchester tonight. Praying for the victims and their families."
Tonight, the American people share the shock and sorrow of the apparent terror attack in Manchester, she said in a statement.
"We are heartbroken by the loss of so many innocent young people, cut down after the joy of a concert. We send our prayers to the families of those killed, to those wounded, and to those still waiting for word from a loved one," she said.
Senator Tom Cotton, condemning the blast, said, "The atrocity in Manchester tonight was horrific. I extend my deepest condolences to the victims and their families. We stand with the British people, and, like them, refuse to be bowed by heinous acts of terror."
House Democratic Whip Steny H Hoyer said there must be no doubt that those who instigated or facilitated this attack will face justice.
"Together we will defeat terror and violence, and together we shall continue to shine the light of democracy across the world. My thoughts and prayers are with the victims and their families tonight and with all the people of Manchester," Hoyer said.
"My thoughts are with Manchester tonight and the loved ones of those lost in this tragic event," tweeted Senator Tom Udall.
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