In the absence of World No. 2 Saina Nehwal, the onus was on Sindhu and Srikanth to lead the Indian charge but the duo couldn't cross the opening hurdle.
Up against top seed and world champion Carolina Marin, Sindhu capitulated 17-21 9-21 to the Spaniard in a women's singles match that lasted round 35 minutes.
Srikanth, who had reached the semifinals of the event last year, suffered his fifth defeat to Tian Houwei of China after his gruelling fight ended with a narrow 16-21 21-15 22-24 loss to the World No. 10 Chinese in a men's singles match that lasted one hour and 13 minutes.
In women's doubles, 2010 Commonwealth Games champions Jwala Gutta and Ashwini Ponnappa lost 12-21 15-21 to eighth-seeded Korean pair of Jung Kyung Eun and Shin Seung Chan in their tournament-opener.
Srikanth gave a tough fight to Tian as he drew parity twice at 7-7 and 10-10 in the opening game but the Chinese was always a step ahead of the Indian.
In the decider, Tian surged ahead 4-0 but Srikanth soon clawed back at 7-7 and in fact held a four-point lead at 14-10 at one stage but the Chinese caught up with him and after a gruelling fight, managed to surpass the Indian.
Sindhu had defeated All England champion, Carolina at the Denmark Open last month but today the Spaniard didn't give any chance to the Indian as she opened up a 5-2 lead early on in the opening game and held fort despite Sindhu clawing back twice at 6-6 and 16-16.
In the evening, India's H S Prannoy too suffered a loss after Japan's Kenta Nishimoto notched up a 21-15 18-21 21-6 win over the Indian in another men's singles match.
In the first game, Kenta opened up a 3-0 lead and even though Prannoy clawede back at 4-4, the Japanese surpassed him from 6-6 and didn't allow him to come closer as he pocketed the game.
Prannoy turned the tables in the second game when he lead 5-2 initially and then managed to stave the challenge from Kenta, who kept breathing down his neck all through out.
