The president of track and field's world governing body hailed the portal, available in Arabic, Chinese, English, French, Russian and Spanish and launched on Tuesday, as "an important platform" in the fight against doping in the sport.
"Within the first 48 hours we had a total of 43 (leads)," Coe said Thursday.
"It will confidentially and securely allow people to report on information on doping into a centralised system."
Coe added: "We must stand tall for clean athletes. The future of our sport relies on the entire athletics community doing everything it can to oppose cheating.
Information the IAAF wants to hear about includes evidence or suspicions of doping, knowledge of coaches and support personnel encouraging doping, trafficking of prohibited substances and new doping products.
"Every piece of information, no matter how small, is important and may be crucial in uncovering doping," the IAAF said.
"The more information you provide, the more likely it is that your information can be successfully followed up.
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