Field Marshal Sisi, who is also Egypt's defence minister and deputy prime minister, and Fahmy would hold "2+2" talks with their Russian counterparts, army spokesman Colonel Ahmed Aly said in a statement.
The talks would focus on "bilateral relations and aspects of cooperation between the two countries", the statement said.
Egypt foreign ministry spokesman Badr Abdelatty told AFP the two men had today left Cairo for a visit to Russia that would last two days.
Russia's top diplomat Sergei Lavrov and Defence Minister Sergei Shoigu visited Cairo for two days mid-November to discuss weapons sales as well as political and economic ties.
That visit came amid tension between Egypt and its longtime ally the United States, which has suspended some of its military aid to Cairo after Sisi toppled Islamist president Mohamed Morsi in July.
Egypt had close ties with Russia before then president Anwar Sadat made peace with Israel in 1979, bringing in roughly USD 1.3 billion in annual US military aid over the subsequent decades.
Sisi, who is hugely popular after ousting the unpopular Morsi, is expected to stand in upcoming presidential elections, which he is likely to win by a landslide.
