Roger Federer, Rafael Nadal and Novak Djokovic share top billing on 'Manic Monday' at Wimbledon with teenage sensation Coco Gauff.
Eight-time champion Federer, four-time winner Djokovic and Nadal, a double champion, all play last 16 ties against opponents who have never before progressed this far.
Federer, the second seed, tackles Italy's world number 20 Matteo Berrettini in what will be the Swiss great's record 17th fourth round appearance at the All England Club.
"I don't know him very well, so that makes it a bit more tricky," said Federer, chasing a 21st Grand Slam title.
Nadal, the champion in 2008 and 2010, also has an unexpected opponent in the shape of world number 69 Joao Sousa, the first Portuguese player to reach the fourth round at Wimbledon.
Nadal has a 2-0 career advantage over the 30-year-old Sousa, with both wins coming on clay.
"He's a super dangerous opponent against everybody. He is very quick, has a very good physical performance," said Nadal, looking to back up his 12th Roland Garros title with a third Wimbledon.
- Djokovic faces grass court rookie -
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- 'Keep it up' -
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"Then you have a 15-year-old like Coco who knows what to do."
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