The massive fire in the 52-unit complex broke out around 12:30 a.M. ET in L'Isle-Verte, about 140 miles (225 kilometers) northeast of Quebec City.
Initial reports said 20 residents had been transported to safety, but it was unclear just how many residents were missing in the inferno. Quebec Provincial Police Sgt. Ann Mathieu said today authorities were trying to determine the exact number of victims and learn the cause of the blaze.
Acting mayor Ginette Caron said many of unaccounted were confined to wheelchairs and walkers, noting that only five residents in the center were fully autonomous. She said some had Alzheimer's disease.
"I got up to go to the toilet and I saw smoke," Michaud told local newspaper Info Dimanche.
"The fire had started on the second floor. I woke up my girlfriend and called 911. I saw the firefighters and they got to work. A woman on the second floor was shouting and she went out on to the balcony. Her son went to get a ladder but he couldn't get to her. She burned to death."
Local chief firefighter Yvon Charron called it "a night from hell."
Several fire departments in the region were called in to help extinguish the blaze, which completely destroyed the building.
The fire comes just six months after 47 people were killed in Lac-Megantic, Quebec, when a train with 72 oil tankers derailed and exploded in the small community.
Canadian Prime Minister Stephen Harper tweeted today that his thoughts and prayers go out to the "families and friends of those lost in this morning's horrific fire in L'Isle-Vert."
In 1969, a nursing home fire in the community of Notre-Dame-du-Lac, Quebec, claimed 54 lives.
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