Fish better than fish oil supplements: Study

Eating fish has greater health benefits than fish oil dietary supplements, according to a new study.
Researchers said Omega-3 fatty acids found in oily fish may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems.
But how the health effects of one such fatty acid - docosahexaenoic acid (DHA) - works remains unclear, in part because its molecular signalling pathways are only now being understood.
Toshinori Hoshi, professor of Physiology, at the Perelman School of Medicine, University of Pennsylvania, and colleagues showed how fish oils help lower blood pressure via vasodilation at ion channels.
In vascular smooth muscle cells, such as those that line blood vessels, ion channels that span the outer membrane of a cell to let such ions as sodium, calcium, and potassium in and out, are critical to maintaining proper vessel pressure.

The researchers found that DHA rapidly and reversibly activates these channels by increasing currents by up to 20 fold. DHA lowers blood pressure in anaesthetised wild type mice but not in mice genetically engineered without a specific ion channel subunit, according to the study published in Proceedings of the National Academy of Sciences.

In comparison, the team found that a dietary supplement, DHA ethyl ester, found in most fish oil pills fails to activate the same channels, and even antagonises the positive effect of DHA from natural sources, on the cells. The DHA ethyl ester seems to compete with the natural form of DHA for binding sites on the ion channel.

The team concluded that these channels have receptors for long-chain omega-3 fatty acids, and that DHA - unlike its ethyl ester cousin - activate the channels and lower blood pressure.
The findings have practical implications for the use of omega-3 fatty acids as nutraceuticals for the general public and also for critically ill patients who may receive omega-3�enriched formulas as part of their nutrition.
Coauthor Michael Bauer from Jena University Hospital in Germany said the findings may encourage physicians to have a closer look at the specific formulations given to sepsis patients as they may contain either the free omega-3 acid or the ester.

The findings also underscore the importance of obtaining omega-3 fatty acids from natural food sources such as oily fish.