He was 70 and is survived by wife, two sons and daughters.
Naidu, a member of the Andhra Pradesh Legislative Council, was admitted to a private hospital in Hyderabad following complaints of high fever two days ago.
He breathed his last in wee hours today, family sources said.
The mortal remains of the TDP leader would be brought to his native village Venkataramapuram, 30 km from here, from Hyderabad later, they said.
Meanwhile, Andhra Pradesh Chief Minister N Chandrababu Naidu and several political leaders expressed shock and grief over the sudden demise of Gali Muddu Krishnama Naidu.
Born in 1947, Naidu had joined politics after a career in teaching as college lecturer, when the actor-turned politician NT Rama Rao floated the TDP in the 1982, party sources said.
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