"She knows that globalization hasn't been good for everybody; that we've got to do something about changing the way in which we deal with the world, and without cutting back on engaging the world," Biden said an election rally in Tampa, Florida, a battleground state.
"She knows a lot of things we can do right now," he said.
The vice-president said any country that will out-educate the US will out-compete it.
Biden played a key role in shaping the foreign policy of the Obama administration.
Referring to some of Republican presidential nominee Donald Trump's remarks, he said they were "un-American".
"The crudeness of it, the denigration of people. It is in a generic sense un-American. People aren't used to hearing this kind of vitriol coming from a candidate for president of the United States of America," he said.
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