The 14-time Grand Slam champion looked back to his healthy best after an injury-riddled 2016 as he beat the 49th-ranked Mayer 6-3 6-4 6-4 in just over two hours on Rod Laver Arena.
He will next play Cypriot Marcos Baghdatis in the second round.
Last year Nadal was dumped out of the Open in the first round by compatriot Fernando Verdasco in a five-set boilover but there was no likelihood of a repeat ambush by Mayer.
"He doesn't have the typical game so he's going to the net. He changes a lot with different points," Nadal said of his German opponent.
"Today was a good first round for me. Florian is a tough first player to play against."
Nadal is bidding to win his second Australian Open after beating Roger Federer for the 2009 crown.
But a left wrist injury plagued the Spanish left-hander after the French Open last year and he missed Wimbledon.
"I was healthy enough to practise the way I wanted to practise, so that's important for me and I was able to work a lot of things in Majorca and happy to be back," Nadal said.
Nadal took the opening set on his fifth set point with an ace and fought off Mayer to grab the second set.
His trademark never-say-die retrieving behind the baseline was a feature as he fought for every point.
Nadal broke Mayer's service in the ninth game of the final set with a forehand winner and served out for a straight sets victory.
Disclaimer: No Business Standard Journalist was involved in creation of this content
You’ve reached your limit of {{free_limit}} free articles this month.
Subscribe now for unlimited access.
Already subscribed? Log in
Subscribe to read the full story →
Smart Quarterly
₹900
3 Months
₹300/Month
Smart Essential
₹2,700
1 Year
₹225/Month
Super Saver
₹3,900
2 Years
₹162/Month
Renews automatically, cancel anytime
Here’s what’s included in our digital subscription plans
Exclusive premium stories online
Over 30 premium stories daily, handpicked by our editors


Complimentary Access to The New York Times
News, Games, Cooking, Audio, Wirecutter & The Athletic
Business Standard Epaper
Digital replica of our daily newspaper — with options to read, save, and share


Curated Newsletters
Insights on markets, finance, politics, tech, and more delivered to your inbox
Market Analysis & Investment Insights
In-depth market analysis & insights with access to The Smart Investor


Archives
Repository of articles and publications dating back to 1997
Ad-free Reading
Uninterrupted reading experience with no advertisements


Seamless Access Across All Devices
Access Business Standard across devices — mobile, tablet, or PC, via web or app
