The United States and its five negotiating partners, the other members of the UN Security Council and Germany, hope to clinch a deal setting long-term limits on Tehran's enrichment of uranium and other activity that could produce material for use in nuclear weapons.
Both sides are under increasing pressure ahead of two deadlines: to agree on main points by late March, and to reach a comprehensive deal by June 30.
"This is the opportunity to do it, and we need to seize this opportunity," he said. "It may not be repeated."
Following a 90-minute morning meeting with US Secretary of State John Kerry, their second meeting on the sidelines of the conference, Zarif said he felt that progress had been made in the past months and suggested it would be unproductive to further extend negotiations.
The possibility of an agreement with Iran prompted strong words today from Israeli Prime Minister Benjamin Netanyahu, who told a weekly Cabinet meeting "we will do everything to thwart a bad and dangerous deal that will cast a dark cloud on the future of the state of Israel and its security."
The US State Department characterised today's discussion between Zarif and Kerry as "constructive." In their meeting on Friday, Kerry pressed Zarif on the Obama administration's desire to meet an end of March target date for the outline of a nuclear agreement.
From Tehran, Supreme Leader Ayatollah Ali Khamenei, who has the final say on all major decisions, said in a statement on his website today that Iran agrees with Washington that no agreement is better than an agreement that doesn't meet its interests.
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