Capshaw and Drew, who play Arizona Robbins and April Kepner respectively in the ABC's hit medical drama currently in season 14, have been associated with the series since 10 and nine installments.
Creator and executive producer Shonda Rhimes said the two characters played an important role in representing both "LBGTQ and devout Christian communities", which had not received the space they deserve on television, according to The Hollywood Reporter.
"It's always hard for me to say goodbye to any of my characters. Both Arizona Robbins and April Kepner are not only beloved but iconic - both the LBGTQ and devout Christian communities are underrepresented on TV. I will be forever grateful to both Jessica and Sarah for bringing these characters to life," Rhimes said in a statement.
"The characters of Arizona and April are permanently woven into the fabric of 'Grey's Anatomy' thanks to the extraordinary work of Jessica Capshaw and Sarah Drew. As writers, our job is to follow the stories where they want to go, and sometimes that means saying goodbye to characters we love," Vernoff.
Capshaw took to Twitter to respond to the news of her departure from the show, saying it had been a privilege to play Arizona for a decade and she is thankful to Rhimes for this.
Drew said she was "sad" after she received the information of her exit from the series and she was not ready to say her "thank yous" yet.
After the announcement, many implied that Capshaw and Drew's departures were linked to the main lead Ellen Pompeo's massive USD 20 million deal recently.
"It smacks of an old, broken, patriarchal notion that women must be pitted against each other and that one woman's success will be costly to others. Ellen Pompeo has not only advocated passionately for her fellow cast members, she has taken the time to educate women worldwide as to how to advocate for themselves and that must not now be twisted. The decision to make changes to our cast was a creative one..." she tweeted.
Pompeo also called out a website on Twitter saying it was unfortunate that media was trying to pit women against each other on International Women's Day (March 8).
"I'm a big girl @DEADLINE can take shots at me if they want but to the fans please don't fall into that trap. This is above my pay grade," she tweeted.
Capshaw and Drew become the second and third series regulars to exit "Grey's Anatomy" this season.
They join Martin Henderson, who was written out after a two-season run.
Disclaimer: No Business Standard Journalist was involved in creation of this content
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