Nine women and three men were selected as jurors for the trial at London's Old Bailey court, the first time criminal charges have been put to the alleged key players in the scandal that rocked the British establishment two years ago.
Two former editors of the tabloid -- Murdoch's protege Rebekah Brooks and Andy Coulson, a former media chief to Prime Minister David Cameron -- are among the eight defendants appearing on charges ranging from illegally hacking celebrities' phones to concealing evidence and bribing officials for stories.
Coulson, Brooks and her racehorse trainer husband Charlie -- who is also on trial -- stood alongside the other defendants and listened impassively as the charges against them were read out.
Judge John Saunders warned the jurors that there was an exceptionally high level of publicity around the trial and that they would need to be careful to avoid coverage of the case, including on social networking sites.
"In this case in a way not only are the defendants on trial, but British justice is on trial," he told them.
Brooks started out as a secretary and eventually became chief executive of Murdoch's British newspaper operations, News International, which was recently rebranded as News UK.
She is charged with phone hacking, conspiracy to commit misconduct in a public office, and perverting the course of justice.
She was editor of the News of the World in 2002 when the tabloid illegally accessed the voicemail messages of murdered schoolgirl Milly Dowler -- the explosive revelation that brought the paper down nearly a decade later.
Brooks' husband Charlie, her former personal assistant Cheryl Carter and former News International security chief Mark Hanna are charged with helping her to hide evidence in the frantic last days of the News of the World.
Also on trial are former News of the World managing editor Stuart Kuttner and head of news Ian Edmondson -- charged with phone hacking -- and the paper's royal editor Clive Goodman, who is accused of bribing officials.
More than 100 people have been arrested since July 2011 as part of a huge police investigation into criminal practices by the British press.
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