The "Creed" filmmaker is adapting the comic book for the big screen and he wants the 33-year-old "12 Years a Slave" star to join him, according to The Hollywood Reporter.
Boseman was introduced as the Black Panther in the new Captain America movie earlier this month.
N'yongo's character has not been revealed, but insiders suggest she's circling the role of the title character's love interest.
"Black Panther" is scheduled to hit cinemas in February, 2018.