The House of Commons was expected to approve the EU (Withdrawal) Bill, which repeals the 1972 law which made Britain a member of the European Union and transfers four decades of EU rules onto the British statute books.
But the unelected upper House of Lords may insist on further changes when the bill moves there for scrutiny later this month, while ministers still face opposition from the devolved Scottish and Welsh administrations.
MPs have tabled hundreds of amendments to the bill in recent weeks, many of them focused on its sweeping powers to both change EU regulations as they are transferred and to authorise any Brexit agreement with the bloc.
Eleven members of Prime Minister Theresa May's Conservative party joined with opposition lawmakers last month to force a change ensuring that parliament will have a "meaningful vote" on the final withdrawal deal.
Fearful of another loss, the government conceded to give MPs the power to amend the date and time of Brexit -- set out in the bill as 2300 GMT on March 29, 2019 -- if talks with the EU appeared to overrun.
"I hope and believe that the other place (the Lords) will make an enormous number of changes to this bill," he said.
The Scottish and Welsh governments have also warned against what they describe as a "power grab" in the bill, which would see some powers in devolved areas of policymaking currently held in Brussels, taken back to London.
May said discussions were continuing with Edinburgh and Cardiff, adding that an amendment on devolved powers would be tabled to the bill when it reached the House of Lords.
Former attorney general Dominic Grieve, who led the Tory rebellion last month, warned: "Unless we're realistic about that we can't hope to get a reasonable outcome to our negotiations."
Justine Greening, who resigned as education secretary in a reshuffle earlier this month, warned that if Brexit did not work for young people, "it will not be sustainable" and they may seek to "improve or undo what we've done".
Britain and the EU reached preliminary agreement before Christmas on the key separation issues -- Britain's financial settlement after Brexit, EU expatriate rights and the future of the Irish border.
However, May has yet to set out her precise vision for the future, and while some members of her cabinet want to stay as close as possible to the single market, others favour a clean break.
European Council President Donald Tusk on Tuesday said the EU's "hearts were still open" if Britain decided to change its mind about leaving the bloc.
His comments followed a remark by leading Brexit campaigner Nigel Farage that he might be open to a second referendum in Britain on EU membership, to silence critics.
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