The girls were "seven or eight", a local militia member in Maiduguri, Abdulkarim Jabo, told AFP.
Emergency services on-site in the town, the epicentre of the Boko Haram jihadist insurgency, said 17 people sustained injuries.
Maiduguri militia-man Jabo said he saw the girls today immediately before the explosion.
"They got out of a rickshaw and walked right in front of me without showing the slightest sign of emotion," he said.
"I tried to speak with one of them, in Hausa and in English, but she didn't answer. I thought they were looking for their mother," he added.
The attack was not immediately claimed by Boko Haram but bore all the hallmarks of the jihadists, who have regularly used women and young girls to carry out suicide attacks in their seven-year insurgent campaign in the troubled region.
On Friday at least 45 people died and 33 others were wounded in another double suicide attack carried out by female bombers in the northeast.
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