Obama's remarks came as he opened a three-day trip to the Caribbean and Central America where he's expected to attend a regional summit with Cuban President Raul Castro.
Havana has eagerly sought removal from the list, and Obama for months has signaled he's prepared to to take the step once he received a formal recommendation.
"Throughout this process, our emphasis has been on the facts," Obama said. "We want to make sure that given this is a powerful tool to isolate those countries that genuinely do support terrorism, that when we make those designations, we've got strong evidence that's the case and as circumstance change, that list will change as well."
Obama's comments came on the first full day of his trip to Jamaica and Panama, where Obama is hoping to make inroads in the face of expanding Chinese influence and weakening power by Venezuela, once the energy juggernaut of the Americas.
The visit comes amid a perception that Obama's interest in the region has failed to materialize. Yet his travels first to Jamaica, then to the Summit of the Americas in Panama follow a year of increased attention to the region by the US president.
His immigration executive orders, his efforts to slow the influx of Central American minors to the US border, and his diplomatic outreach to Cuba have put a foreign policy spotlight on US neighbors to the south.
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