Two gunmen, who were on a motorcycle, opened fire at Sajid Qureshi and his son when they emerged from a mosque in North Nazimabad area after Friday prayers.
Qureshi, a legislator of the Muttahida Quami Movement party, was killed instantly while his son succumbed to his injuries at a nearby hospital.
Business activities came to a standstill in the area after the killings and shops and offices were closed.
Qureshi was recently elected a member of the Sindh Assembly.
No group claimed responsibility for the killings.
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