Researchers found that compared with the least active women, those with the highest level of physical activity reduced their risk of breast cancer by 12 per cent.
Professor Mathieu Boniol, Research Director at the International Prevention Research Institute, Lyon, France, reported the results of a meta-analysis of 37 studies published between 1987 and 2013, representing over four million women.
"These are all the studies looking at the relationship between physical exercise and breast cancer risk that have been published to date, so we are confident that the results of our analysis are robust," he said.
However, in women taking hormone replacement therapy (HRT), the protective effect of exercise seemed to be cancelled out.
But increased awareness of the side effects of HRT means that its use is decreasing in a number of countries, and this means that the beneficial effects of activity will most likely grow in the years to come, researchers said.
Physical activity is known to have a protective role in other cancers, as well as in disorders such as cardiovascular disease.
Although the mechanisms for its effect are unclear, the results are largely independent of body mass index (BMI), so the effect must be due to more than weight control.
The study was presented at the 9th European Breast Cancer Conference in Glasgow.
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