Graeme Smith's Proteas have dominated the five-day format and are unbeaten in a Test series since losing to Sri Lanka in 2006.
Their record against sub-continent teams is particularly impressive as they have lost only four out of their last 20 Tests against such opposition and just once in an away series.
South Africa have beaten Pakistan in 11 of their 21 Tests, losing only three and drawing the remaining seven.
Pakistan's only series win came way back in 2003 on home ground.
Even the dusty and dry pitches of the United Arab Emirates, where Pakistan have been forced to play their home matches since the 2009 terror attack on a Sri Lankan team bus, hold no fears for the South Africans.
They drew a two-Test series in the UAE in 2010 with Jacques Kallis hitting successive hundreds, AB de Villiers notching South Africa's then highest score of 278 not out and Smith and Hashim Amla also scoring centuries.
Smith, who returns to international cricket following an ankle injury in March, believes his side are ready for all possibilities.
"We expect the wickets to spin, we expect the worst in that regard, and know that how we handle Ajmal could be the key," said Smith.
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