McGowan got into the shouting match with the attendee during the Barnes and Noble event, held in New York City, where the actor was promoting her memoir Brave.
The trans woman stood up during the Q&A segment and made a reference to McGowan's comments that she made in July 2last year on RuPaul's "What's the Tee?" podcast.
"I have a suggestion. Talk about what you said on RuPaul. Trans women are dying and you said that we, as trans women, are not like regular women. We get raped more often. We go through domestic violence more often," the woman said before McGowan cut her off.
The woman also accused McGowan of doing nothing for the trans women.
"Trans women are in men's prisons. And what have you done for them?" she asked.
After that, both the women started yelling at each other. The attendee was later escorted away by the security.
As the woman was being escorted, McGowan had a meltdown and she broke into a monologue which was filled with expletives.
Following the incident, the actor has cancelled her upcoming public appearances.
"I am cancelling upcoming public appearances because I have given enough. I have given beauty, in return I was verbally assaulted for two full minutes by an actor paid to verbally assault a woman who has been terrorised by your system. And no one in that room did anything," she tweeted.
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