The seventh-seeded Saina was no match for World No.1 Xuerui, who took just 45 minutes to sent packing the Indian with identical 15-21 15-21 scoreline.
With this victory at the Ballerup Super Arena, the Chinese had extended her head-to-head win-loss record against Saina to 8-2.
Olympic bronze medallist Saina, who had to fought her way back from a game down to register a 14-21 21-18 21-12 win over Sayaka Takahashi of Japan in the previous round, looked rusty from the start and was trailing Xuerui in the entire first game.
But just when it seemed Saina is slowly getting her acts together, the Chinese regrouped herself and increased her lead to 18-11 before closing down the first game.
The second game was more competitive as it was neck-and-neck fight between Saina and Xuerui till the first five points before the Indian pocketed four consecutive points to lead 9-5.
Saina maintained her four point lead till 12-8 before Chinese shuttler earned four straight points to draw level at 12-all.
From 13 apiece, Xuerui again won four consecutive points to take the lead for the first time in the game and then sealed the match in her favour with another straight points.
Xuerui will play 16th seed Minatsu Mitani of Japan in the semifinals. Mitani stunned fifth seede Ji Hyun Sung of Korea 9-21 21-18 22-20 in hard-fought contest.
Another Indian in fray, 11th seed P V Sindhu will play second seed Shixian Wang of China in another quarterfinal late today.
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