The Saudi Interior Ministry said early today that the crash happened yesterday in Saudi Arabia's Asir province as the official took part in a tour of local projects near Abha, some 160-km from the border with Yemen.
Saudi Arabia has been leading a military coalition against Yemen's Houthi rebels since March 2015.
Security officials gave no cause for the crash, but said a search of the wreckage was underway.
In Yemen, Houthi officials offered no immediate comment on the crash, while the group's Al-Masirah satellite news channel reported only that the crash had occurred.
Prince Mansour was the son of Prince Muqrin bin Abdulaziz, a former intelligence service director and one-time crown prince. Prince Muqrin was removed as crown prince in April 2015 by his half brother King Salman in favour of Prince Mohammed bin Nayef, a counter-terrorism czar and interior minister.
But in June, King Salman also ousted Prince Mohammed in favour of the king's 32-year-old son, the now-Crown Prince Mohammed bin Salman, as first in line to the throne.
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