The incident took place around 9 am at Jadcherla, 90 km from here, police said.
The girls, class 10 students, were heading for their class when the car hit them, a local police official said.
S Murali (37), the school principal, was driving the car, he added.
"Both the girls were rushed to a nearby hospital. B Ramyasri succumbed to injuries, while the other girl is undergoing treatment," the police official told PTI.
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