The 26-0 vote by the Senate Finance Committee now moves Lighthizer's nomination to the full Senate.
Lighthizer served as deputy US trade representative under President Ronald Reagan. He has also worked on trade issues as a lawyer representing various manufacturers and high-tech companies.
Lighthizer will take his cues from a president who has broken with most Republicans in his criticism of free trade agreements. Lighthizer, who has assailed some Republicans for being too pro-free trade, told the Senate panel earlier this year that the US should have an "America-first trade policy."
"What's the president team did yesterday was send the message that help was on the way," Wyden said.
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