The 30-share barometer declined 96.80 points, or 0.32 per cent, to 29,324.60 with sectoral indices led by metal, teck, IT, healthcare, oil&gas, FMCG and auto trading in negative zone with losses up to 0.86 per cent.
The index had risen about 254 points in the previous two sessions.
Also, the NSE Nifty slipped below the crucial 9,100-level by falling 33.15 points, or 0.36 per cent, at 9,074.85.
Brokers said that apart from profit-booking in recent gainers, a weak trend in Asia following Donald Trump's failure to push through his healthcare legislation kept shares depressed here.
In the Asian region, Hong Kong's Hang Seng shed 0.16 per cent, while Japan's Nikkei was down 1.51 per cent in early sessions. Shanghai's Composite Index, however, was up 0.16 per cent.
The Dow Jones Industrial Average ended 0.29 per cent lower in Friday's trade.
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