Skin microbes trigger specific immune responses

The immune system in the skin triggers distinct responses to the various microbes that naturally colonise the skin, researchers, including one of Indian-origin, have found.
New research in mice shows that the immune system in the skin develops specific responses to various microbes referred to as commensals.
A team led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, found that each type of microbe triggers unique aspects of the immune system, suggesting that immune cells found in the skin can rapidly sense and respond to changes in microbial communities.

These findings help clarify the protective role of skin commensals and may help explain how variation in the microbes at different skin sites contributes to skin disorders.
The skin is home to diverse microbial communities that can change over time.
In the current study, investigators, including Shruti Naik from Rockefeller University, found that colonising mice with different commensals leads to production of commensal-specific immune cells.

They describe in detail how the common skin commensal Staphylococcus epidermidis enhances immune responses against pathogens without causing inflammation.
Colonising the skin of mice with S epidermidis increased the number of CD8+ T immune cells, which produced the chemical messenger IL-17A.

Dendritic cells, another type of immune cell, played a key role in generating this specific, non-inflammatory response.
Mice colonised with S epidermidis were protected against infection with a disease-causing fungus. Depleting CD8+ T cells or neutralising IL-17A removed this protective effect.
The ability of different microbes to trigger distinct aspects of the immune system without causing inflammation opens the possibility of discovering new adjuvants - immune-boosting substances that may be added to vaccines or medications.