Spaceflight ups astronauts' risk of inflammatory bowel disease

Prolonged spaceflight may change the balance of bacteria and the function of immune cells in the gut, leading to increased bowel inflammation in astronauts, a new study on mice suggests.
Researchers subjected mice to simulated spaceflight conditions and found that the microbiome of mouse intestines underwent changes that render the gut prone to inflammation.
"Our study provides useful insights on the cross-regulation of the mucosal immune system, epithelial barrier and commensal bacteria not only in humans in spaceflight or analog, but also in humans on earth that undergo various stresses," said study author Qing Ge, from the Department of Immunology at Peking University Health Science Centre in China.

To make their discovery, Ge and colleagues used four groups of mice. The first and third groups were suspended for 14 days by the tail at a 15 degree head-down tilt with their hindlimbs suspended.
Access to food and water was ensured using both water bottles and gel packs and food distributed around the floor of the cage.
Animals demonstrated no adverse effects or pronounced weight loss. The second and fourth groups were normal.

Starting from day seven, the third and the fourth groups were fed with three per cent dextran sulfate sodium dissolved in drinking water to induce inflammatory bowel disease whereas the first and the second groups received plain water.

Compared to the second ground control group, the first group with hindlimb suspension showed altered composition of intestinal bacteria, decreased regulatory T cells, increased neutrophils, and imbalance of pro- and anti-inflammatory cytokines in the colon tissues.
The third group with hindlimb suspension had more severe pathology of inflammatory bowel disease when compared to the fourth control group.
This includes more weight loss, more severe rectal bleeding and tissue damage and increased death rate in the hindlimb suspended mice after colitis induction.
"We already know that a trip to Mars and back may well have serious, possibly permanent, effects on the bodies of the astronauts," said Gerald Weissmann, Editor-in-Chief of The FASEB Journal, in which the study was published.

"Now we learn that the hidden passengers on that mission - the bacteria in their gut - will be affected as well," Weissmann said.