The bombing marks the second deadly attack in the city since Wednesday, when Islamic State jihadists claimed responsibility for a deadly gun and bomb siege targeting the Pakistani consulate.
The latest attack came during a "jirga", an assembly of tribal leaders, at the home of politician Obaiduallah Shinwari, who escape unscathed.
"Thirteen people were killed and 14 others injured when a suicide bomber targeted the house of Shinwari," said a statement from the governor of Nangarhar province, of which Jalalabad is the capital.
The uptick in violence comes amid renewed international efforts to revive peace talks with the Taliban, locked in a tussle for supremacy with the Islamic State group in Afghanistan.
Last week representatives of Afghanistan, Pakistan, the United States and China met in a bid to revive stalled Taliban peace talks, even as the insurgents wage a brazen winter campaign of violence.
The so-called "roadmap" talks were meant to lay the groundwork for direct dialogue between the Afghan government and the Islamists to end the 14-year Taliban insurgency.
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