In an interview with NBC News, Assad was asked to comment on a lawsuit filed by Colvin's relatives in US federal court claiming that Syrian government officials targeted and killed Colvin to silence her reporting on Syria and the besieged central city of Homs.
"Nobody knows if she (was) killed by missile, or which missile, and where did the missile come from, or how. No one has any evidence," Assad said.
Assad's government uses the term "terrorist" for all armed opposition fighters and militants battling his forces, whether they are Western-backed rebels or al-Qaeda and other Islamic fighters.
The lawsuit filed last week said Syrian officials launched a rocket attack on a makeshift broadcast studio in a neighborhood of Homs on February 22, 2012, killing Colvin, along with French photojournalist Remi Ochlik.
Just hours before her death, the 56-year-old Colvin, a native of New York City, had filed another report on the Syrian government's crackdown and its impact on civilians.
The Syrian government has contended that its attacks targeted "terrorists."
"When you're caught in crossfire somewhere, you cannot tell who killed who ... These are all allegations," Assad said.
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