The study found that 33 per cent of adults recently diagnosed with asthma by their physicians did not have active asthma.
Over 90 per cent of these patients were able to stop their asthma medications and remain safely off medication for one year, researchers said.
"It's impossible to say how many of these patients were originally misdiagnosed with asthma, and how many have asthma that is no longer active," said lead author of the study, Shawn Aaron, professor at the University of Ottawa in Canada.
Eighty per cent of the participants who did not have asthma had been taking asthma medication, and 35 per cent took it daily.
The study also found that doctors often did not order the tests needed to confirm an asthma diagnosis. Instead they based their diagnosis solely on the patient's symptoms and their own observations.
"Doctors would not diagnose diabetes without checking blood sugar levels, or a broken bone without ordering an X-ray," said Aaron.
The study looked at 613 randomly selected patients from 10 Canadian cities diagnosed with asthma in the last five years.
After a series of detailed breathing tests followed by consultation with a lung specialist, asthma was ruled out in a third of these patients.
The team was able to access the medical records of 530 of the patients to see how they were originally diagnosed. They found that in 49 per cent of these cases, physicians had not ordered the airflow tests required by medical guidelines.
Two per cent had serious conditions like pulmonary hypertension or heart disease that had been misdiagnosed as asthma, and went on to receive proper treatment.
"It was not a surprise to most patients when we told them they did not have asthma," said Aaron.
"Some knew all along that their puffer was not working, while others were concerned that they might have something more serious. Thankfully, the majority of the conditions were mild and easily treated," he said.
The study was published in the Journal of the American Medical Association.
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