Trott, who pulled out of England's tour of Australia and spent four months out of the game with what the ECB described as a "stress-related illness", experienced a repeat of the same symptoms after playing for his county Warwickshire against Sussex on Wednesday.
A statement released jointly by the ECB and Warwickshire said Trott "will now undergo further treatment to assist with his long-term rehabilitation."
Trott himself said: "It was with the best intentions and hope that I returned to cricket with Warwickshire this month.
"It is not fair on my team-mates or myself to continue when I am unable to function at 100 per cent. In order to play at the highest level you have to be at 100 per cent and be able to concentrate fully at all times. Sadly I am unable to do this.
"With this in mind I have decided it is best for all involved that I continue my recovery on the sidelines for the time being."
Trott, who turns 33 next week, pulled out of the Ashes tour after the first Test in Brisbane and spent four months away from the game working with a psychologist and the ECB's medical team in a bid to rebuild his career.
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