The movie from Morgan Creek Productions is distributed by Lionsgate's Summit Entertainment.
The biopic follows the story of Shakur's rise to stardom as a hip-hop artist, actor, poet and activist, The Hollywood Reporter said.
It will also feature Shakur's imprisonment and his controversial time at Death Row Records.
The movie's title is named after Shakur's fourth studio album which was released in 1996 and sold 10 million of the 75 million in total sales of Shakur's albums.
Other cast members are including Katerina Graham, Dominic Santana, Hill Harper, Jamal Woolard, Keith Robinson and "The Walking Dead" co-stars Lauren Cohan and Danai Gurira.
The project was previously delayed due to some troubles during pre-production phase.
A series of directors exited the project, including Antoine Fuqua, Carl Franklin and John Singleton. Veteran music video director Benny Boom eventually helmed "All Eyez On Me."
Shakur was killed in September 1996 in a drive-by shooting in Las Vegas when he was only 25.
The story of his life and death has been featured in at least a dozen documentaries. The late rapper is set to be inducted into the Rock and Roll Hall of Fame on April 7.
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