The bus tipped over after sliding on an icy road in a town in the Kayseri province, governor Orhan Duzgun told Turkish television.
"The number of the dead has risen to 21, with one injured losing his life in hospital," said Duzgun.
He added that some of the passengers died when they jumped out of the vehicle's windows. Duzgun also said that the death toll could rise as two passengers were seriously injured.
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