It was not immediately known if the car was driven by a suicide bomber or not, the security source said, requesting anonymity.
No group has claimed responsibility for the dawn attack that partially destroyed the finance ministry branch in Khour Maksar in the temporary capital.
Aden has witnessed a series of bombings including suicide attacks that have killed hundreds of people, some of them claimed by the Islamic State jihadist group.
A Saudi-led coalition has been fighting an alliance of pro-Iran Huthi militias and forces loyal to former president Ali Abdullah Saleh since March 2015.
The Yemen war has killed more than 8,650 people, the majority civilians, and pushed the country to the brink of famine.
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